Back to Search Start Over

SGLT2i effect on atrial fibrillation: A network meta‐analysis of randomized controlled trials.

Authors :
Mariani, Marco Valerio
Manzi, Giovanna
Pierucci, Nicola
Laviola, Domenico
Piro, Agostino
D'Amato, Andrea
Filomena, Domenico
Matteucci, Andrea
Severino, Paolo
Miraldi, Fabio
Vizza, Carmine Dario
Lavalle, Carlo
Source :
Journal of Cardiovascular Electrophysiology; Sep2024, Vol. 35 Issue 9, p1754-1765, 12p
Publication Year :
2024

Abstract

Introduction: Gliflozins are recommended as first‐line treatment in patients with heart failure and/or cardiovascular comorbidities and are demonstrated to reduce atrial fibrillation (AF) occurrence. However, it is not well known which gliflozin yields the larger cardioprotection in terms of AF occurrence reduction. Hence, we aimed to compare data regarding AF recurrence associated with different gliflozins. Methods: An accurate search of online scientific libraries (from inception to June 1, 2023) was performed. Fifty‐nine studies were included in the meta‐analysis involving 108 026 patients, of whom 60 097 received gliflozins and 47 929 received placebo. Results: Gliflozins provided a statistically significant reduction of AF occurrence relative to standard of care therapy in the overall population (relative risks [RR]: 0.8880, 95% CI: [0.8059; 0.9784], p =.0164) and in patients with diabetes and cardiorenal diseases (RR: 0.8352, 95% CI: [0.7219; 0.9663], p =.0155). Dapagliflozin significantly decreased AF occurrence as compared to placebo (0.7259 [0.6337; 0.8316], p <.0001) in the overall population, in patients with diabetes (RR: 0.2482, 95% CI: [0.0682; 0.9033], p =.0345), with diabetes associated with cardiorenal diseases (RR: 0.7192, 95% CI: [0.5679; 0.9110], p =.0063) and in the subanalysis including studies with follow‐up ≥1 year (RR: 0.7792, 95% CI: [0.6508; 0.9330], p =.0066). No significant differences in terms of AF protection were found among different gliflozins. Conclusions: Dapagliflozin use was associated with significant reduction in AF risk as compared to placebo in overall population and patients with diabetes, whereas the use of other gliflozins did not significantly reduce AF occurrence. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10453873
Volume :
35
Issue :
9
Database :
Complementary Index
Journal :
Journal of Cardiovascular Electrophysiology
Publication Type :
Academic Journal
Accession number :
180986369
Full Text :
https://doi.org/10.1111/jce.16344