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Phytoconstituents of Endiandra kingiana; antidiabetic effects and molecular docking studies on alpha-amylase and alpha-glucosidase.

Authors :
Tanazi, Nurul Najihah Husna
Aziz, Ahmad Nazif
Azmi, Mohamad Nurul
Abu Bakar, Mohamad Hafizi
Hassim, Muhamad Fairus Noor
Wahab, Nurul Huda Abdul
Rasol, Nurulfazlina Edayah
Ab Ghani, Nurunajah
Maulidiani, M.
Awang, Khalijah
Source :
Natural Product Research; Dec2024, Vol. 38 Issue 24, p4375-4382, 8p
Publication Year :
2024

Abstract

Phytochemical investigation on the bark of E. kingiana plant afforded ten compounds, including six polyketides namely kingianin A 1, kingianin B 2, kingianin E 3, kingianin F 4, kingianin K 5 and kingianin L 6, three endiandric acids; kingianic acid A 7, tsangibeilin B 8 and endiandric acid M 9, and one sesquiterpene; daibuoxide 10. All compounds were separated as racemic mixture by recycling high-performance liquid chromatography (RHPLC), except for daibuoxide. Their structures were elucidated by detailed spectroscopic and comparative literature data analysis. This is the first report on the presence of the sesquiterpene; daibuoxide in Endiandra genus. In vitro enzymatic bio-evaluation of the isolated compounds against α-amylase and α-glucosidase showed that 4 demonstrated the best α-amylase and α-glucosidase inhibitory activity with IC<subscript>50</subscript> values of 181.54 ± 6.27 µg/mL and 237.87 ± 0.07 µg/mL, respectively. In addition, molecular docking analysis confirmed the α-amylase and α-glucosidase inhibitory activities demonstrated by 4. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14786419
Volume :
38
Issue :
24
Database :
Complementary Index
Journal :
Natural Product Research
Publication Type :
Academic Journal
Accession number :
180967998
Full Text :
https://doi.org/10.1080/14786419.2023.2283759