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Telomere length as a biomarker for cerebrovascular diseases: current evidence.

Telomere length as a biomarker for cerebrovascular diseases: current evidence.

Authors :
da Cunha Agostini, Lívia
da Silva, Glenda Nicioli
Source :
Molecular Biology Reports; 11/13/2024, Vol. 51 Issue 1, p1-12, 12p
Publication Year :
2024

Abstract

Cerebrovascular disease (CVD) includes a range of conditions affecting the brain's blood vessels, which can result in reduced blood flow to brain tissue. The most common manifestation of CVD is stroke, the second leading cause of death and the third leading cause of disability worldwide. Major risk factors for CVD encompass gender, age, smoking, hypertension, diabetes, physical inactivity, obesity, alcohol consumption, and metabolic syndrome. Research suggests a link between telomere length and an increased risk of CVD, particularly in ischemic stroke cases. This review highlights key findings on the relationship between telomere length and CVD, underscoring its clinical importance. The analysis utilizes scientific literature from PubMed, Scopus, and SciELO up to 2024. Results show that shorter telomere length is associated with various types of CVD, including stroke, ischemic stroke, hemorrhagic stroke, and cardioembolic stroke. Some studies propose that telomere length measurement could be a valuable biomarker for CVD, potentially improving prevention, diagnosis, and management strategies. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03014851
Volume :
51
Issue :
1
Database :
Complementary Index
Journal :
Molecular Biology Reports
Publication Type :
Academic Journal
Accession number :
180905911
Full Text :
https://doi.org/10.1007/s11033-024-10077-8