Targeting sleep physiology to modulate glymphatic brain clearance (Updated November 5, 2024).

The article discusses the relationship between sleep and the glymphatic system's role in clearing neurotoxic molecules from the brain, potentially preventing neurodegenerative diseases like Alzheimer's and Parkinson's. It explores various interventions, including sensory, transcranial stimulation, pharmacological, and behavioral modifications to enhance brain clearance during sleep. The review emphasizes the importance of promoting efficient brain clearance through sleep interventions to combat neurodegeneration, cognitive decline, and dementia. The preprint has not undergone peer review and provides a comprehensive overview of potential preventative and therapeutic applications of sleep interventions. [Extracted from the article]