The −KTS isoform of Wt1 induces the transformation of Leydig cells into granulosa-like cells.

The article in Cell Discovery discusses the transformation of Leydig cells into granulosa-like cells through the overexpression of the Wt1-KTS isoform. The study explores the role of Wt1 in gonadal development and differentiation, specifically focusing on the impact of Wt1-KTS overexpression on Leydig and Sertoli cells. The findings suggest that Leydig cells can be transformed into granulosa-like cells under specific conditions, shedding light on the cellular dynamics of gonadal development. The research provides valuable insights into the differentiation processes of gonadal somatic cells and their implications for reproductive system development. [Extracted from the article]