Synthesis, Evaluation of the Biological Activity and AntiOxidant for Some Heterocyclic Compounds Seven-membered Rings Derived from Schiff Bases.

In this study, Some new Compounds have been Synthesized including the preparation of some Schiff bases (P1,P2,R4) from the reaction Benzdine, 2-aminoanthracine-9,10-dione compounds with two moles of various aldehydes The second stage includes preparation of new heterocyclic compounds seven membered rings ( Oxazepine, Oxazepane)(P1C1,P1C2,P1C3,P2C1,P2C2,P2C3,R4C1,R4C2,R4C3) using the microwave method . The prepared compounds were characterized by FT-IR, 1H-NMR, and 13C-NMR spectra in addition melting points were measured for all compounds and reactions was followed by TLC (Thin Layer Chromatography).Finally, the synthesized compounds are tested against Gram-positive(Staphylococcus aureus) and Gram-negative bacteria (Escherichia Coli) to study their biological activity, the results showed high biological effectiveness of some derivatives (P1,P2,R4,P1C1,P1C2,P1C3,P2C1,P2C2,R4C1) compared with Ciprofloxacin drug and study anti-oxidant for the R4C2 compound which gave good results. . [ABSTRACT FROM AUTHOR]