Evaluation the effectiveness of oral gel containing pomegranate peel extract in treatment of periodontitis.

Background and Aim: The goal of this project is to introduce an oral gel of plant origin for the treatment of gingivitis and periodontitis that is thought to have significant therapeutic effects while not having the side effects of common chemical agents. Due to no toxic and systemic side effects and on the other hand, given the antibacterial, antifungal, antiviral, anti-inflammatory, antioxidant, and astringent components of this product, it is assumed to be useful in clinical studies. Materials and Methods: The study was triple blinded. The study population consisted of 32 patients (n=32) with moderate to severe periodontitis. The study included both men and women between the ages of 22 years-60 years for three months. Initially, two teeth in two different quadrants with deep pockets were considered in each patient. Each tooth and gels that has to been injected around teeth, were randomly selected. At the beginning, plaque index, gingival index, clinical attachment loss, pocket depth, bleeding index were measured and recorded. All patients treated with scaling and root planning, then one periodontal pocket of each patient was injected with pomegranate gel and another periodontal pocket was injected with placebo. The syringe was 1 ml and 27 gauge, then Coe-pack placed on both teeth. The trial interval was one and three months. After one and three months of the first session, variables were evaluated again. Results: There was no statistically significant difference in plaque index, gingival index, clinical attachment loss, pocket depth and bleeding index at baseline between pomegranate gel and placebo. There was a statistically significant reduction in all mentioned variables one and three months after the beginning of the study in the tooth containing pomegranate gel (p<0.001). There was a significant reduction in plaque index, gingival index, clinical attachment loss, pocket depth and bleeding index in tooth containing pomegranate between the beginning of the study with one and three months follow-up (p<0.001). There was a significant reduction in plaque index, gingival index, clinical attachment loss, pocket depth and bleeding index in tooth containing placebo between the beginning of the study with one and three months follow-up (p<0.001). Conclusion: The results of this study show that gel containing pomegranate peel extract can have good therapeutic effects on plaque index, gingival index, clinical attachment loss, pocket depth and bleeding index. [ABSTRACT FROM AUTHOR]