New MELAS Syndrome Study Findings Recently Were Published by a Researcher at University of Parma (Advancing cardiac 3D organoid-on-chip: integrating iPSC-derived MELAS syndrome models to study electromechanical synchronicity and cardiac memory...).

Researchers at the University of Parma recently published a study on MELAS syndrome, a rare mitochondrial disorder that affects various organs, including the heart. The study utilized hiPSCs to create 3D cardiac organoids to investigate the electromechanical properties of cardiomyocytes with the MELAS mutation. Findings revealed significant differences in beating frequency, contractile speed, and response to electric field stimulation between MELAS and control cells, shedding light on the cardiac impact of this complex syndrome. The research provides valuable insights into the physiological and kinematic parameters of MELAS, potentially informing future investigations and benefiting affected tissues. [Extracted from the article]