National University of Science and Technology Researchers Illuminate Research in Cancer Gene Therapy (The Internalization Pathways of Liposomes, PLGA, and Magnetic Nanoparticles in Neutrophils).

Researchers at the National University of Science and Technology in Moscow, Russia, conducted a study on the internalization pathways of liposomes, PLGA, and magnetic nanoparticles in neutrophils for cancer gene therapy. The study aimed to enhance the efficiency of neutrophil-based nanodrug delivery for cancer treatment by investigating the mechanisms of nanoparticle internalization. Different nanoparticles were successfully internalized by neutrophils, with uptake mechanisms varying, and the presence of plasma in the medium significantly influencing nanoparticle binding. Understanding distinct endocytosis pathways for different nanoparticles can potentially improve the efficacy of neutrophil loading with nanodrugs for cancer therapies. [Extracted from the article]