Reports Outline Genetics Study Results from University of Illinois (Non-electrophilic NRF2 activators promote wound healing in human keratinocytes and diabetic mice and demonstrate selective downstream gene targeting).

Researchers at the University of Illinois have conducted a study on non-electrophilic NRF2 activators, ADJ-310 and PRL-295, and their effectiveness in promoting wound healing in human keratinocytes and diabetic mice. The study compared these compounds to the widely used electrophilic NRF2 activator CDDO-Me and found that ADJ-310 and PRL-295 showed promising results in vitro and in vivo. The research highlights the potential of these non-electrophilic compounds as innovative tools for studying NRF2 function and their therapeutic potential in various disease states. For more information, readers can refer to the article published in Scientific Reports. [Extracted from the article]