Ameliorative Effect of Polypodium vulgare L. Rhizome on Anxiety and Depressive-Like Behaviors in Restraint-Subjected Mice: Involvement of Inflammatory, Oxidative and Apoptotic Pathways.

The article presents a study which evaluated the anxiolytic and antidepressant effects of the hydroethanolic extract of common polypody rhizome (PEE) and the possible underlying mechanisms in mice subjected to chronic restraint stress (CRS). Topics discussed include the popularity of complementary and alternative medicine (CAM) for mental disorders, measurement of total phenolic and flavonoid content, and antioxidant and lipid peroxidation measurement.