MAGNETIC DISPERSIVE SOLID-PHASE EXTRACTION OF CIPROFLOXACIN DRUG AS β-CYCLODEXTRIN FUNCTIONALIZED MAGNETIC NANOTUBES ON Fe3O4 NANOPARTICLES.

This project introduced a fast way for the adsorption of low amounts of ciprofloxacin in aqueous samples using β-cyclodextrin functionalized magnetic nanotubes (Fe₃O₄/NT/BD). In this method, the donor phase contains (water phase with ciprofloxacin) and the phase of the acceptor (functionalized magnetic nanotubes with β-cyclodextrin). Two steps of the Experiment were performed in the extraction of ciprofloxacin from the water sample and ciprofloxacin desorption with basic methanol. The Langmuir model isotherm was well described the ciprofloxacin adsorption, and the ciprofloxacin capacity in the maximum sorption was 30.12 mg/g. The pseudo-second-order kinetic model confirming the adsorption of ciprofloxacin by Fe₃O₄/NT/BD is limited in rate following the chemisorption process. The limit of detection and quantification factors for ciprofloxacin adsorption were 15.9 and 51.2 µg/L, respectively. A linear range parameter was attained between 1-10 mg/L. Finally, the Fe₃O₄/NT/BD presented a high potential for ciprofloxacin adsorption from biological samples. [ABSTRACT FROM AUTHOR]