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Efficacy of Cytoreg in the treatment of diabetic foot disease.
- Source :
- Journal of Wound Care; Nov2024, Vol. 33 Issue 11, p806-812, 7p
- Publication Year :
- 2024
-
Abstract
- Objective: Complications from diabetic foot wounds, including bacterial infection, ulceration and gangrene, are major causes of hospitalisation and are responsible for 85% of amputations in patients with diabetes. Given that orally administered investigational therapeutic Cytoreg (Cytorex de Venezuela SA, Venezuela), a defined aqueous mixture of hydrofluoric, hydrochloric, sulfuric, phosphoric, citric and oxalic acids, has been shown to increase levels of arterial blood oxygen in a Wistar rat model, oral and oral+topical Cytoreg were tested on patients with diabetic foot ulcers (DFUs) under a humanitarian, compassionate-use protocol. Method: All patients received oral Cytoreg (5.0 ml concentrate in fruit juice) for 30 days; half also received weekly wound washing with Cytoreg concentrate in isotonic saline (1:50 volume/volume) (oral+topical group). In addition to standard clinical observations, wounds were monitored against the Saint Elian checklist system for the diabetic foot. Results: A total of 10 patients took part in the study. Complete wound closure was observed in 4/5 patients in the oral+topical group; in the remaining patient, necrotic and fibrin tissues on the wound edges were eliminated. Half (2/4) of the patients receiving oral-only Cytoreg experienced complete wound closure; one patient in this group was removed prematurely because of an unrelated illness and was not replaced. During the study, no significant differences were observed between groups in either the oxygen saturation of the affected tissues or in insulin and glycaemia levels (p<0.05). Significant increases in arterial haemoglobin and arterial oxygen partial pressure (p<0.05) were observed, and significant decreases were measured in the levels of glycosylated haemoglobin, aspartate aminotransferase, glutamic-pyruvic transaminase, creatine and urea (p<0.05). Conclusion: The results of this study justify an expanded clinical study for the treatment of DFUs with Cytoreg. [ABSTRACT FROM AUTHOR]
- Subjects :
- CUTANEOUS therapeutics
WOUND healing
OXYGEN saturation
PHYSIOLOGIC salines
GLYCOSYLATED hemoglobin
T-test (Statistics)
INVESTIGATIONAL drugs
SULFURIC acid
PHOSPHORIC acid
ASPARTATE aminotransferase
PILOT projects
ORAL drug administration
HYDROFLUORIC acid
HYDROCHLORIC acid
OXALIC acid
INSULIN
DESCRIPTIVE statistics
MANN Whitney U Test
ARTERIAL pressure
DIABETIC foot
DRUG efficacy
ALANINE aminotransferase
CREATINE
UREA
TYPE 2 diabetes
WOUND care
CITRATES
DATA analysis software
PARTIAL pressure
Subjects
Details
- Language :
- English
- ISSN :
- 09690700
- Volume :
- 33
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Journal of Wound Care
- Publication Type :
- Academic Journal
- Accession number :
- 180592961
- Full Text :
- https://doi.org/10.12968/jowc.2022.0024