Hydroxymethylglutaryl co-enzyme A reductase inhibition attenuates endotoxin-mediated inflammatory responses.

Authors :: Joyce, M.
Casey, R.
Gang, C.
Winter, D.
Kelly, C. J.
Bouchier-Hayes, D. J.
Source :: British Journal of Surgery; Aug2005, Vol. 92 Issue 8, p1034-1040, 7p
Publication Year :: 2005
Abstract: Investigates the attenuation of endotoxin-mediated inflammatory responses to hydroxymethylglutaryl co-enzyme A reductase inhibition. Alteration of the expression of endothelial constitutive nitric oxide synthase; Utilization of intravital microscopy to determine leucocyte-endothelial cell interactions; Release of proinflammatory cytokines.

Subjects :: DEHYDROGENASES
ENDOTOXINS
HYDROXYMETHYLGLUTARYL coenzyme A reductases
CYTOKINES

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