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Nanostructured cobalt(II) phthalocyanine modified screen‐printed electrodes for the determination of thiocyanate in human saliva.

Authors :
Pavelka, Vit
Lazanas, Alexandros Ch.
Sarigiannidou, Myrto
Hrbac, Jan
Prodromidis, Mamas I.
Source :
Electroanalysis; Oct2024, Vol. 36 Issue 10, p1-8, 8p
Publication Year :
2024

Abstract

Salivary thiocyanate is a biomarker of individual health that notably allows for the discrimination between smokers and non‐smokers. Recent studies have also demonstrated its potential as a biomarker of cystic fibrosis, thus rendering the development of methods for its determination in saliva of immense importance. In response, we report on the development of graphite screen‐printed electrodes (SPE) modified with cobalt(II) phthalocyanine nanosticks (CoPcNst), as low‐cost and semi‐disposable sensors for the determination of thiocyanate ion (SCN−) in human saliva. CoPCNst were synthesized and characterized using scanning electron microscopy, x‐ray diffraction, as well as infrared and Raman spectroscopies. The results revealed a structural proximity to the recently identified J‐polymorph. Compared with the electrode modified with commercial, beta‐structure cobalt(II) phthalocyanine, the CoPc Nst/SPE provided four times better LOD and LOQ (0.49 and 1.62 μM) for thiocyanate determination by differential pulse voltammetry. The response was linear up to 20 μM SCN− (R2=0.996) and it was not affected by excess of common electro active compounds, such as ascorbic and uric acid. The analytical utility of CoPc Nst/SPE in human saliva is demonstrated. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10400397
Volume :
36
Issue :
10
Database :
Complementary Index
Journal :
Electroanalysis
Publication Type :
Academic Journal
Accession number :
180520674
Full Text :
https://doi.org/10.1002/elan.202400011