Anti-Proliferative Effect of Biosynthesized Zinc-Oxide Nanoparticles Using Albizia Lebbeck Leaves Extract Against Arsenic-Induced Liver Cancer in Rats.

The most common type of cancer is hepatocellular carcinoma (HCC). The current study aimed to induce hepatocellular injury in the Wistar rat model through the administration of arsenic at a dose rate of 5mg/kg. In the context of treating induced liver toxicity, biocompatible nanocomposites were proposed as a drug delivery system. The proposed intervention involved administering a nanomaterial consisting of zinc oxide and Albizia lebbeck intraperitoneal at a dose rate of 10 mg/kg for 8 weeks. For this research, 24 Wistar rats were divided into four distinct groups. Except for the normal control group, rats from each group were administered intraperitoneal injections of arsenic oxide every other day for 56 days, at a dosage of 5 milligrams per kilogram of body weight, to induce hepatocellular carcinoma. The HCC that has been developed went under evaluation through various methods, including histopathology, complete blood count, health markers, and ultrasonography. The decrease in HCC dimensions was ascertained through the use of ultrasonography. The statistical analysis of the acquired data was involved the use of ANOVA and the least significant difference at a significance level of 5%. [ABSTRACT FROM AUTHOR]