An examination of the poor correlation between symptoms and signs of dry eye disease.

Introduction: This review examines how mechanisms that are not related to tear dysfunctions may contribute to the development of symptoms of dry eye disease and help to explain why dry eye symptoms do not correlate with signs. Consideration is also given to the significance of tear deficiencies which cannot contribute to an examination of symptom-sign correlation. Areas covered: Tear deficiencies which are not routinely assessed include inflammation, mucin quantity and quality, as well as corneal neuropathy and blink inefficiency. Expert opinion: Tear deficiencies detected in an examination of patients reporting symptoms of dry eye disease become the targets for remedial approaches but not always with satisfactory outcomes. Other possible influences on symptoms could include genetic predispositions, sex, ethnicity, race, health literacy, mental health conditions, lower perceived health-related quality of life, and psychological factors. However, these possible influences cannot be assessed in most dry eye disease clinical settings. Consequently, too often symptoms of dry eye cannot correlate with signs of tear dysfunction that are not identified (and so not treated). Consequently, noncompliance with treatment recommendations may not be relevant to the persistence of symptoms or signs when treatment does not address tear dysfunctions which are difficult to assess. [ABSTRACT FROM AUTHOR]