Differential expression and modulation of presenilin-1 and presenilin-2 in neural cell lines.

The article discusses the differential expression and modulation of Presenilin-1 (PS1) and Presenilin-2 (PS2) in neural cell lines, which are crucial components of the γ-secretase enzyme involved in Alzheimer's disease pathogenesis. The study highlights the distinct roles of PS1 and PS2 in γ-secretase activity and their compensatory responses in various cell types. Understanding the expression profiles of PS1 and PS2 is essential for developing targeted therapeutics for Alzheimer's disease. The preprint has not yet undergone peer review. [Extracted from the article]