A systematic review of aperiodic neural activity in clinical investigations.

The article discusses the increasing interest in studying aperiodic neural activity in clinical investigations, particularly in relation to psychiatric and neurological disorders. A systematic literature review found 143 reports across 35 distinct disorders, with a majority showing a significant effect in diagnostic and treatment-related studies. However, there is variability in results due to patient heterogeneity, disease etiologies, and treatment status, suggesting further research is needed to establish aperiodic activity as a potential biomarker or marker of underlying pathology. Recommendations are proposed to guide future work in this area. [Extracted from the article]