Ethanol drinking sex-dependently alters cortical IL-1b synaptic signaling and cognitive behavior in mice.

The article discusses the impact of chronic ethanol drinking on cognitive function and interleukin-1β (IL-1β) synaptic signaling in male and female mice. It highlights how ethanol consumption affects memory and IL-1 receptor 1 (IL-1R1) mRNA levels in the medial prefrontal cortex (mPFC) of both sexes. The study suggests that understanding the sex-dependent effects of IL-1β on mPFC dysfunction in alcohol use disorder (AUD) could lead to the development of new pharmacotherapeutics targeting biased IL-1 signaling. [Extracted from the article]