Research from Army Medical University Provide New Insights into Apoptosis (BMSCs-derived exosomes overexpressing TGM2 inhibit lactate-induced oxidative stress related apoptosis in nucleus pulposus cells).

Researchers from Army Medical University in Chongqing, China, conducted a study on the role of exosomes derived from bone marrow mesenchymal stem cells (BMSCs) overexpressing transglutaminase 2 (TGM2) in inhibiting lactate-induced oxidative stress-related apoptosis in nucleus pulposus cells. The study involved experiments on rats to explore the mechanisms of TGM2-overexpressing exosomes in reducing apoptosis rates and reactive oxygen species (ROS) levels in nucleus pulposus cells. The findings suggest that exosomes from BMSCs overexpressing TGM2 can effectively inhibit oxidative stress-induced apoptosis in nucleus pulposus cells by activating the PI3K/Akt/Nrf2 pathway. [Extracted from the article]