The effect of mesoporous silica doped with silver nanoparticles on glass ionomer cements; physiochemical, mechanical and ion release analysis.

Background: The purpose of the study was to evaluate the effect of adding mesoporous silica with silver nanoparticles to conventional glass ionomer cements (GIC) on its, physical, chemical, mechanical properties and ion release analysis. Methods: Synthesized mesoporous silica with silver nanoparticles were added in 1, 3 and 5% by weight to the liquid component of GIC forming three experimental groups and compared with plain GIC as control group. Physical and chemical characterization were conducted using nano-computerized tomography (NanoCT) and Fourier transform infrared spectroscopy. Surface microhardness, water sorption and solubility were analyzed. Ion release was investigated using Inductive Coupled Plasma-Optical Emission Spectroscopy and High Performance Liquid Chromatography. Statistical analysis between different groups for the set parameters using parametric and non-parametric tests. The results were analysed using one way analysis of variance (p < 0.05). Results: Synthesized mesoporous silica with silver nanoparticles were of 7.28 ± 5.0 nm in diameter with a spherical morphology. NanoCT revealed less porosities for 3 wt %. Microhardness showed a statistically significant difference for 5 wt% at day 1 and 21 (p < 0.0001). Water sorption values decreased significantly on day 14 compared to day 7 for control, 1, 3 and 5 wt%. Control specimens showed highest concentration of fluoride release followed by 5, 3 and 1 wt%. Conclusion: Mesoporous silica with silver nanoparticles modified glass ionomer cements showed comparable microhardness to conventional GIC. Ion release was evident from the modified specimens. Silver remained within the GIC for atleast four weeks following incorporation. [ABSTRACT FROM AUTHOR]