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Mitotic ER-mitochondria contact enhances mitochondrial Ca2+ influx to promote cell division.

Mitotic ER-mitochondria contact enhances mitochondrial Ca2+ influx to promote cell division.

Authors :
Zhao, Gan
Jia, Mingkang
Zhu, Shicong
Ren, He
Wang, Guopeng
Xin, Guangwei
Sun, Mengjie
Wang, Xiangyang
Lin, Qiaoyu
Jiang, Qing
Zhang, Chuanmao
Source :
Cell Reports; Oct2024, Vol. 43 Issue 10, pN.PAG-N.PAG, 1p
Publication Year :
2024

Abstract

Cell division is tightly regulated and requires an expanded energy supply. However, how this energy is generated remains unclear. Here, we establish a correlation between two mitochondrial Ca<superscript>2+</superscript> influx events and ATP production during mitosis. While both events promote ATP production during mitosis, the second event, the Ca<superscript>2+</superscript> influx surge, is substantial. To facilitate this Ca<superscript>2+</superscript> influx surge, the lamin B receptor (LBR) organizes a mitosis-specific endoplasmic reticulum (ER)-mitochondrial contact site (ERMCS), creating a rapid Ca<superscript>2+</superscript> transport pathway. LBR acts as a tether, connecting the ER Ca<superscript>2+</superscript> release channel IP 3 R with the mitochondrial VDAC2. Depletion of LBR disrupts the Ca<superscript>2+</superscript> influx surge, reduces ATP production, and postpones the metaphase-anaphase transition and subsequent cell division. These findings provide insight into the mechanisms underlying mitotic energy production and supply required for cell proliferation. [Display omitted] • The number of ERMCSs increases in mitosis • Mitotic ERMCS strengthens the Ca<superscript>2+</superscript> uptake capacity of mitotic mitochondria • LBR binds VDAC2 in mitosis, mediating these mitosis-specific ERMCSs • Mitochondrial Ca<superscript>2+</superscript> influx surge promotes the metaphase-anaphase transition Zhao et al. describe a mechanism by which mitochondrial Ca<superscript>2+</superscript> regulates the metaphase-anaphase transition through LBR-mediated mitosis-specific ER-mitochondria contact sites (ERMCSs). The LBR-mediated ERMCSs promote the mitochondrial Ca<superscript>2+</superscript> influx surge, which is essential for expanded energy generation during mitosis. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
26391856
Volume :
43
Issue :
10
Database :
Complementary Index
Journal :
Cell Reports
Publication Type :
Academic Journal
Accession number :
180364121
Full Text :
https://doi.org/10.1016/j.celrep.2024.114794