Researchers at University of California San Diego (UCSD) Target Gene Therapy (The Future of Therapeutic Options for Hereditary Angioedema).

Researchers at the University of California San Diego are focusing on gene therapy as a potential treatment for hereditary angioedema (HAE), a rare genetic condition that causes severe and unpredictable episodes of angioedema. HAE can be classified into different types based on the underlying genetic mutations, leading to uncontrolled factor activation and excessive bradykinin production. Current management strategies for HAE include on-demand and prophylactic treatments, but ongoing research is exploring additional therapeutic options such as small molecule inhibitors, monoclonal antibodies, RNA-targeted therapies, and gene modification approaches. This review article provides an overview of current HAE treatments and potential future therapies, highlighting the advancements in gene therapy for this condition. [Extracted from the article]