New Findings from Montreal Clinical Research Institute (IRCM) in Ataxia Telangiectasia Provides New Insights (Article Protein Ufmylation Regulates Early Events During Ribosomal Dna-damage Response).

A recent study conducted at the Montreal Clinical Research Institute (IRCM) in Canada has shed light on the role of protein UFMylation in the early events of ribosomal DNA-damage response in Ataxia Telangiectasia. The research highlights the importance of UFMylation in orchestrating DNA double-strand break repair in human cells, particularly in regulating ATM activation and rDNA transcriptional silencing. This study provides valuable insights into the mechanisms underlying the response to genotoxic stress in neurodegenerative diseases like Ataxia Telangiectasia. [Extracted from the article]