New Data from University of Calcutta Illuminate Findings in Ophthalmic Antiinfectives (In Silico Screening of Sulfonamide Derivatives Against Glycolytic Enzymes Reveals Mutation-independent Interactions of Sulfisoxazole and Sulfamethazine).

A study conducted at the University of Calcutta in India focused on the interaction of sulfonamide derivatives with glycolytic enzymes, revealing that sulfisoxazole and sulfamethazine showed significant binding affinities to certain enzymes. The research suggests that these drugs could potentially be repurposed as specific inhibitors to combat glycolysis-related metabolic disorders. The study was funded by the Spanish Government and the Council of Scientific & Industrial Research (CSIR) in India, and the findings have been peer-reviewed and published in ChemistrySelect. [Extracted from the article]