Biochemical Composition, Polyphenol and Flavonoid Content, Antibacterial Activity of Leaf and Flower Extracts of Clerodendrum paniculatum Distributed In Thua Thien Hue Province, Viet Nam.

Clerodendrum paniculatum is a medicinal plant commonly used in Vietnam and many other places worldwide due to its antibacterial, anti-inflammatory, and antioxidant properties. In this study, we investigated the biochemical composition, total flavonoid and polyphenol contents, and antibacterial activity of the leaves and flowers of C. paniculatum found in Thua Thien Hue, Vietnam. The results indicated that some phytochemicals in the powdered leaf and flower of C. paniculatum are safe and suitable for medicinal use, while the flavonoid and polyphenol compounds in the plant materials were also quantified. The leaves and flowers contain antioxidant compounds, reducing sugar, vitamin C, and catalase enzymes. Methanol leaf and flower extracts of C. paniculatum contain significant amounts of total flavonoids and polyphenols, with the flowers having higher levels than the leaves. The flavonoid and polyphenol contents in the flower extract were 17.22 mg catechin/g extract and 373.33 mg GAE/g extract, compared to 6.14 mg catechin/g extract and 266 mg GAE/g extract in the leaf extract. Both leaf and flower extracts exhibited significant antibacterial activity against the test bacteria E. coli and B. subtilis, with stronger effects against E. coli. The flower extract showed better antibacterial effects than the leaf extract, with inhibition zone diameters at a concentration of 750 mg/ml being 15.33 mm for E. coli and 15.00 mm for B. subtilis. This research provides valuable scientific information for the use of this medicinal plant in Thua Thien Hue. [ABSTRACT FROM AUTHOR]