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Squamous cell carcinoma of ear and temporal bone: A retrospective study on clinicopathological predictors.

Authors :
Li, Wei
Tucker, Bronwyn
Hu, Zhan‐Dong
Zhang, Yu‐Jie
Guo, Xue‐Xi
Cai, Wen‐Juan
Zhang, Ming‐Fang
Han, Ya‐Ting
Source :
Head & Neck; Nov2024, Vol. 46 Issue 11, p2870-2877, 8p
Publication Year :
2024

Abstract

Background: Ear and temporal bone squamous cell carcinoma (ETBSCC) is a rare and aggressive malignant tumor with minimal clinicopathological studies. The object of this study was to retrospectively evaluate the predictive effect of clinicopathological variables on the 5‐year overall survival (OS) rate of ETBSCC patients in a single tertiary medical center in Tianjin, China. Methods: A cohort of 44 patients with diagnosed ETBSCC from December 2012 to August 2022 were retrospectively studied. Univariate and multivariate analysis were, respectively, performed for the assessment of clinicopathological predictors, including sex, age, history of chronic suppurative otitis media (CSOM), lesion side, diameter, the choice of surgical approach, parotidectomy, neck dissection, adjuvant therapies, T stage, lymph node metastasis, tumor grade, margin, perineural invasion (PNI), and Ki‐67 index. Results: Seventeen females and 27 males were included, with the mean age of 65 years old, ranging from 36 to 89 years. The 5‐year OS rate was 43% (mean 51 months, 95% confidence interval [CI] = 39–64). Significant prediction of a worse prognosis for 5‐year OS rate was observed under univariate analysis for advanced T stage, positive margin, identified PNI, and higher Ki‐67 index, respectively. Advanced T stage was confirmed to be an independent prognostic factor strongly affecting 5‐year OS rate among this cohort of patients using a multivariate cox proportional hazard model. Conclusion: We found that clinicopathological parameters, especially postoperative pathological parameters, play a critical role in predicting the prognosis of ETBSCC patients. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10433074
Volume :
46
Issue :
11
Database :
Complementary Index
Journal :
Head & Neck
Publication Type :
Academic Journal
Accession number :
180280527
Full Text :
https://doi.org/10.1002/hed.27818