A device for studying heterogeneous tumor cell cultures based on a hybrid microfluidic system.

This study addresses the development of a prototype device for studying cellular structures of various types, including spheroids consisting of tumor cells, in a microfluidic format. The work demonstrates that a microfluidic system (MFS) can be used for effective evaluation of the efficacies of antitumor pharmaceuticals. The MFS supports parallel analysis of small-volume samples obtained by from patients by biopsy and can also be used to study the movement and migration of tumor spheroids. The results obtained here lead to the conclusion that the system has promise for personalized and targeted therapy. [ABSTRACT FROM AUTHOR]