Back to Search Start Over

Plasma itraconazole concentrations during treatment of feline sporotrichosis.

Authors :
Pereira-Oliveira, Gabriela Reis
Gremião, Isabella Dib Ferreira
Corrêa, Maria Lopes
Caroline dos Santos Honorato, Cindy
Gonçalves Viana, Paula
Figueiredo, Anna Barreto Fernandes
Boechat, Jéssica Sepúlveda
Guerino dos Reis, Érica
Oliveira, Raquel de Vasconcelos Carvalhaes
da Silva, Aline Campos de Azevedo
Novotny, Thiago Santana
Guaraldo, Lusiele
Pereira, Sandro Antonio
Source :
Medical Mycology; Aug2024, Vol. 62 Issue 8, p1-8, 8p
Publication Year :
2024

Abstract

Itraconazole (ITZ) is the most used drug to treat feline sporotrichosis; however, little is known about its pharmacokinetics in cats with this mycosis. The aim of this study was to determine plasma ITZ concentrations in cats with sporotrichosis treated with ITZ as monotherapy or in combination with potassium iodide (KI). Cats diagnosed with sporotrichosis received orally ITZ (100 mg/cat/day) or combination therapy with ITZ (100 mg/cat/day) and KI (2.5–5 mg/kg/day) in the case of worsening or stagnation of the clinical condition. At each monthly visit, blood samples were collected at an interval of 4 h for analysis of trough and peak plasma ITZ concentrations by HPLC. Clinical features and laboratory parameters were evaluated during follow-up. Sixteen cats were included in the study. The median plasma ITZ concentration of all cats was 0.75 µg/mL. The median plasma ITZ concentration was 0.5 µg/mL in cats that received ITZ monotherapy (n  = 12) and 1.0 µg/mL in those treated with ITZ + KI (n  = 4). The clinical cure rate was 56.3% (n  = 9) and the median treatment duration was 8 weeks. Nine cats (56.3%) developed adverse clinical reactions, and hyporexia was the most frequent (n  = 8; 88.9%). Serum alanine aminotransferase was elevated in four cats (25%). The median plasma ITZ concentration detected in cats was considered to be therapeutic (>0.5 µg/mL) and was reached after 4 weeks of treatment. Plasma ITZ concentrations were higher in cats that received ITZ + KI compared to those treated only with ITZ, suggesting pharmacokinetic synergism between these drugs. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13693786
Volume :
62
Issue :
8
Database :
Complementary Index
Journal :
Medical Mycology
Publication Type :
Academic Journal
Accession number :
180267937
Full Text :
https://doi.org/10.1093/mmy/myae076