Back to Search Start Over

Ultra-Hypofractionated Whole Breast Radiotherapy with Automated Hybrid-VMAT Technique: A Pilot Study on Safety, Skin Toxicity and Aesthetic Outcomes.

Authors :
Boccardi, Mariangela
Cilla, Savino
Fanelli, Mara
Romano, Carmela
Bonome, Paolo
Ferro, Milena
Pezzulla, Donato
Marco, Roberto Di
Deodato, Francesco
Macchia, Gabriella
Source :
Breast Cancer: Targets & Therapy; Sep2024, Vol. 16, p611-619, 9p
Publication Year :
2024

Abstract

Objectively using a Cutometer equipment. Patients and Methods: Patients received 26 Gy to the whole breast and 30 Gy to the tumoral bed in 5 fractions using an automated hybrid-VMAT approach with the option for the breath hold technique if necessary. Acute and late toxicities were clinically evaluated at baseline, 1- and 6-months after treatment using the CTC-AE v.5.0 scale. An instrumental evaluation of the skin elasticity was performed using a Cutometer<superscript>®</superscript> Dual MP580. Two parameters per patient, R0 (the total skin firmness) and Q1 (the elastic recovery), were registered at the different timelines. Results: From June 2022 to January 2024, 30 patients, stage T1-T2, N0 were enrolled in the study. Four out of 30 (13.3%) patients reported G2 acute skin toxicities. At 6 months, G2 late toxicity was registered in 3 patients (10%). A total of 2160 measures of R0 and Q1 were recorded. At 1 month after treatment, no correlation was found between measured values of R0 and Q1 and clinical evaluation. At 6 months after treatment, clinical late toxicity ≥ 1 was strongly associated with decreased R0 and Q1 values ≥ 24% (p = 0.003) and ≥ 18% (p = 0.022), respectively. Conclusion: Ultra-hypofractionated whole-breast radiotherapy, when supported by advanced treatment techniques, is both feasible and safe. No severe adverse effects were observed at any of the different timeframes. Acute and late skin toxicities were shown to be lower in contrast to data presented in the literature. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
11791314
Volume :
16
Database :
Complementary Index
Journal :
Breast Cancer: Targets & Therapy
Publication Type :
Academic Journal
Accession number :
180251713
Full Text :
https://doi.org/10.2147/BCTT.S470417