Is chest tube capnography effective in differentiating between true and false air leaks after minimally invasive thoracic surgery?

Objective: Air leak (AL) is the most frequent adverse event after thoracic surgery. When AL occurs, the concentration of the principal gas in the pleural space should be similar to that of air exhaled. Accordingly, we tried to develop a new method to identify AL by analyzing pCO₂ levels in the air flow from the chest drainage using capnography. Methods: This is a prospective observational study of 104 patients who underwent VATS surgery between January 2020 and July 2021. Digital drainage systems were used to detect AL. Results: Eighty-two patients (79%) had lung resection. Among them, 19 had post-operative day 1 air leaks (median 67 ml/min). AL patients had higher intrapleural CO₂ levels (median 24 mmHg) (p < 0.001). Median chest drainage duration was 2 days (range 1.0–3.0). Univariable logistic regression showed a linear and significant association between intrapleural CO₂ levels and AL risk (OR 1.26, 95% CI 1.17–1.36, p < 0.001, C index: 0.94). The Univariable Gamma model demonstrated that an elevation in CO₂ levels was linked to AL on POD1 (with an adjusted mean effect of 7.006, 95% CI 1.59–12.41, p = 0.011) and extended duration of drainage placement (p < 0.001). Conclusions: Intrapleural CO₂ could be an effective tool to assess AL. The linear association between variables allows us to hypothesize the role of CO₂ in the identification of AL. Further studies should be performed to identify a CO₂ cutoff that will standardize the management of chest drainage. [ABSTRACT FROM AUTHOR]