Naval Medical University Researchers Yield New Data on Colitis (Toll-Like Receptor 2 Deficiency Exacerbates Dextran Sodium Sulfate-Induced Intestinal Injury through Marinifilaceae-Dependent Attenuation of Cell Cycle Signaling).

Researchers from Naval Medical University in Shanghai, China have conducted a study on the biological impacts of toll-like receptor 2 (TLR2) on inflammation in the intestines of colitis mouse models. The study found that TLR2 deficiency exacerbated intestinal injury caused by dextran sulfate sodium (DSS) and attenuated cell cycle signaling. The researchers also observed notable variations in gut microbiota composition between wild-type and TLR2-knockout colitis mice. The findings suggest that TLR2 plays a protective role in DSS-triggered colitis and that its deficiency worsens intestinal injury through a Marinifilaceae-dependent mechanism. [Extracted from the article]