Patent Application Titled "Genetically Modified Mouse Expressing Human Apoe4 And Mouse Trem2 P.R47h And Methods Of Use Thereof" Published Online (USPTO 20240315220).

The USPTO has published a patent application titled "Genetically Modified Mouse Expressing Human Apoe4 And Mouse Trem2 P.R47h And Methods Of Use Thereof." The application describes a genetically modified mouse model that exhibits symptoms of non-familial late-onset Alzheimer's disease. The mouse model expresses human APOE4 protein and a modified mouse Trem2 protein with a specific mutation. This model can be used for preclinical trials and screening potential treatments for Alzheimer's disease. The patent application was filed by inventors from The Jackson Laboratory. [Extracted from the article]