Roles of Kdm6a and Kdm6b in regulation of mammalian neural regeneration (Updated October 1, 2024).

A preprint abstract from biorxiv.org discusses the role of two histone 3 lysine 27 (H3K27) demethylases, Kdm6a and Kdm6b, in regulating mammalian neural regeneration. The study found that deleting either Kdm6a or Kdm6b enhanced sensory axon regeneration in the peripheral nervous system (PNS), while deleting Kdm6a in retinal ganglion cells (RGCs) significantly enhanced optic nerve regeneration in the central nervous system (CNS). The researchers also discovered that Kdm6a regulates RGC regeneration through a different pathway than Pten, and that deleting both Kdm6a and Pten resulted in long-distance optic nerve regeneration. Additionally, the study identified Klf4 as a downstream target of Kdm6a-H3K27me3 signaling in regulating axon regeneration. This research provides insights into the roles of Kdm6a and Kdm6b in neural regeneration and highlights Kdm6a-mediated histone demethylation signaling as a potential target for supporting CNS neural regeneration. [Extracted from the article]