Longhua District Central Hospital Researchers Discuss Findings in Tumor Cell Line (Knockdown of IGF2BP3 Down-Regulates PDCD4 Levels to Attenuate Hypoxic-Ischemic Brain Damage).

Researchers at Longhua District Central Hospital in Guangdong, China, have conducted a study on tumor cell lines to investigate the function and mechanism of programmed cell death factor 4 (PDCD4) in alleviating hypoxic-ischemic brain damage (HIBD). The study found that PDCD4 and the N6-Methyladenosine (m6A) reader protein IGF2BP3 were up-regulated in an HIBD neonatal rat model. Knockdown of IGF2BP3 in stimulated cells reduced cell damage by down-regulating PDCD4. The findings suggest that the IGF2BP3/PDCD4 axis may play a role in attenuating HIBD. [Extracted from the article]