Van Andel Institute Researchers Focus on Chromatin (Human 8-oxoguanine glycosylase OGG1 binds nucleosome at the dsDNA ends and the super-helical locations).

A recent study conducted by researchers at the Van Andel Institute focused on chromatin and the human glycosylase OGG1 enzyme. The study found that OGG1 plays a crucial role in repairing oxidized DNA bases and is involved in various pathological conditions such as cancer and neurodegenerative diseases. The researchers used cryo-EM structures to examine how OGG1 operates on longer DNA and nucleosomes. They discovered that OGG1 preferentially binds near dsDNA ends at nucleosomal entry/exit sites and can also bend the nucleosomal entry DNA and bind to internal nucleosomal DNA sites. The study suggests that OGG1's DNA base search mechanism may be dependent on the chromatin context and that it may work in conjunction with chromatin remodelers to remove oxidized DNA bases. [Extracted from the article]