Patent Issued for Mammal-specific growth-defective arbovirus (USPTO 12098393).

A patent has been issued to Tengen Biomedical Company for a method of creating growth-restricted arboviruses that replicate in insect cells but not in mammal cells. Arboviruses are a group of viruses that can replicate in both insect and mammal cells and are transmitted by ticks or mosquitoes. The invention aims to produce arbovirus particles that can elicit an immune response in mammals without causing disease or pathology. The method involves altering the furin tetrapeptide recognition site in the virus's precursor polyprotein. [Extracted from the article]