Studies from Lanzhou University in the Area of Obesity, Fitness and Wellness Described (Ccc Pincer Ru Complex-catalyzed C-h Vinylation/6p-e-cyclization of Aldimines for Constructing 4h-pyrido[1,2-a]Pyrimidines).

A study conducted by researchers at Lanzhou University in China has discovered a new method for synthesizing polycyclic 4H-pyrido[1,2-a]pyrimidine derivatives, which could be used in the development of new drug candidates. The researchers used a unique CCC pincer NHC-Ru(III) complex to achieve a cascade C-H activation, vinylation, and 6 pi-electrocyclization reaction. The reaction was found to have a broad substrate scope and resulted in mostly good to high yields. This research was supported by various institutions, including Shanghai Jiao Tong University and the National Natural Science Foundation of China. [Extracted from the article]