CYP14 family in Caenorhabditis elegans: Mitochondrial function, detoxification, and lifespan.

CYP‐14 members of the Caenorhabditis elegans (C. elegans) Cytochrome P450 (CYP) enzyme family, plays important roles in mitochondrial dysfunction, detoxification, lipid metabolism, defense and lifespan regulation. The review identifies CYP‐14 members: cyp‐14A1, cyp‐14A2, cyp‐14A3, cyp‐14A4, cyp‐14A5 and their homology with human CYP families. Despite limited studies on C. eleganscyp‐14 members, the findings unraveled their complex crosstalk between mitochondrial stress, detoxification mechanisms, and lifespan regulation, emphasizing the complexity of these interconnected pathways as well as how their regulation depends on environmental cues changes including pH, nutrients, ROS and chemical stressors. The review underscores the translational relevance to human health, shedding light on potential human homologues and their implications in age‐related, metabolic and respiratory diseases. Among other genes, cyp‐14A2 and cyp‐14A4 predominate the mitochondrial function, heat resistance, lipid metabolism, detoxification and lifespan pathways. In conclusion, these insights pave the way for future research, offering promising avenues for therapeutic interventions targeting CYP‐14 activity to address age‐related diseases and promote healthy aging. The C. elegans Cytochrome P450 family members CYP‐14A1‐5 regulate mitochondrial function, detoxification, lipid metabolism, defense, and lifespan. Limited studies reveal complex crosstalk between these pathways, emphasizing interconnected regulation dependent on pH, nutrients, ROS, and chemical stressors. Translational studies of CYP‐14A2/4 shed light on homologous human CYPs and implications in age‐related, metabolic, and respiratory diseases. Further CYP‐14 research offers therapeutic promise for healthy aging. [ABSTRACT FROM AUTHOR]