Patent Application Titled "Method Of Treatment Of Depressed Patients With Poor Cognition And Selection Of Other Patients Benefiting From A Benzylpiperazine-Aminopyridine Agent" Published Online (USPTO 20240307377).

This document is a patent application for a method of treating major depressive disorder in patients with cognitive impairment or poor cognition. The inventors propose administering a specific medication, NSI-189, to these patients, despite previous reports of its ineffectiveness. The method involves objectively assessing cognitive impairment or poor cognition in patients and administering the medication alongside other antidepressant medications. The patent application also includes methods for treating late-life depression and provides specific dosage recommendations for the medication. [Extracted from the article]