Researcher at University of California Releases New Study Findings on Acute Lymphoblastic Leukemia (Abstract C076: Increased AID results in mutations at the CRLF2 locus implicated in Latin American ALL health disparities).

A recent study conducted at the University of California has found that increased levels of activation-induced cytidine deaminase (AID) in immature B cells can lead to mutations at the CRLF2 locus, which is associated with a subtype of acute lymphoblastic leukemia (ALL) that disproportionately affects Hispanics, particularly those with Latin American ancestry. The researchers developed a digital PCR assay to quantify these mutations and found increased mutations in both Hispanic ALL patients and healthy Hispanic donors. This research has important implications for risk identification, early detection of cancers, and reducing health disparities in Latin American ALL. [Extracted from the article]