Studies from University of Jaen Add New Findings in the Area of Primary Hyperoxaluria (Tracking Selective Internalization and Intracellular Dynamics of Modified Chitosan Polymeric Micelles of Interest In Primary Hyperoxaluria Diseases).

Researchers from the University of Jaen in Spain have conducted a study on primary hyperoxaluria (PH), a rare kidney disease caused by disruptions in glyoxylate metabolism. The researchers focused on designing polymeric micelle nanocarriers to selectively transport and release inhibitors of the hepatic lactate dehydrogenase A enzyme (hLDHA) into liver tissues. They synthesized and assessed the internalization and disaggregation dynamics of chitosan-based polymeric micelles in both hepatic and nonhepatic cell models. The results showed that the nanocarriers had higher selectivity for hepatic cells and demonstrated no cytotoxic effects. [Extracted from the article]