New Bronchopulmonary Dysplasia Findings from Pennsylvania State University (Penn State) Health Described (Omic-signature of Bronchopulmonary Dysplasia Associated Pulmonary Hypertension In <1500g-birth-weight-infants With Hemodynamically...).

A recent study conducted by researchers at Pennsylvania State University (Penn State) Health examined the transcriptomic expression and associated pathways in tracheal aspirates (TAs) of low-birth-weight infants with hemodynamically significant cardiac shunt (ICS) who develop bronchopulmonary dysplasia (ICS-BPD) and pulmonary hypertension (ICS-BPD-PH). The study found that there were differentially expressed miRNAs and mRNAs in the ICS-BPD-PH group compared to the ICS-BPD group. The findings suggest that these molecules may play a role in the pathogenesis of bronchopulmonary dysplasia-associated pulmonary hypertension in low-birth-weight infants with intracardiac shunts. The research was supported by various organizations and has been peer-reviewed. [Extracted from the article]