Researchers from Soochow University Detail New Studies and Findings in the Area of siRNA-Based Therapy (Biomimetic Nanocomplexes Orchestrate Post-stroke Cerebral Microenvironment Via Microglia-targeted Sirna Delivery).

Researchers from Soochow University in Suzhou, China have developed biomimetic nanocomplexes (NCs) to deliver siRNA targeted at microglia to modulate the inflammatory cerebral microenvironment in post-stroke ischemia-reperfusion (IR) injury. The NCs consist of a cationic nano-core and an outer shell made from a platelet-microglia hybrid membrane. The NCs are able to accumulate at the lesion site, penetrate the blood-brain barrier, and enter microglia to release siRNA and silence sphingosine kinase 1 (SPHK-1), thereby remodeling the inflammatory microenvironment and protecting the neurovascular unit. This bio-inspired strategy shows promise for gene therapy against cerebral diseases. [Extracted from the article]