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Researchers from Soochow University Detail New Studies and Findings in the Area of siRNA-Based Therapy (Biomimetic Nanocomplexes Orchestrate Post-stroke Cerebral Microenvironment Via Microglia-targeted Sirna Delivery).
- Source :
- Gene Therapy Weekly; 10/11/2024, p3279-3279, 1p
- Publication Year :
- 2024
-
Abstract
- Researchers from Soochow University in Suzhou, China have developed biomimetic nanocomplexes (NCs) to deliver siRNA targeted at microglia to modulate the inflammatory cerebral microenvironment in post-stroke ischemia-reperfusion (IR) injury. The NCs consist of a cationic nano-core and an outer shell made from a platelet-microglia hybrid membrane. The NCs are able to accumulate at the lesion site, penetrate the blood-brain barrier, and enter microglia to release siRNA and silence sphingosine kinase 1 (SPHK-1), thereby remodeling the inflammatory microenvironment and protecting the neurovascular unit. This bio-inspired strategy shows promise for gene therapy against cerebral diseases. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 10782842
- Database :
- Complementary Index
- Journal :
- Gene Therapy Weekly
- Publication Type :
- Periodical
- Accession number :
- 180081073