Patent Issued for Methods for multi-resolution analysis of cell-free nucleic acids (USPTO 12094573).

A patent has been issued to Guardant Health Inc. for methods of multi-resolution analysis of cell-free nucleic acids. The patent describes a method for enriching nucleic acid samples for nucleosome-associated regions of a genome using bait sets. These bait sets selectively enrich for regions with differential nucleosomal occupancy, which can indicate the cell or tissue type of origin or a disease state. The method involves bringing the nucleic acid sample in contact with a bait set panel and enriching the sample for the target sequences. The patent also includes claims related to sequencing the enriched nucleic acids and analyzing the sequencing reads to determine nucleosomal patterns and profiles. [Extracted from the article]