Study Results from University of Catania Broaden Understanding of Prostatic Hyperplasia (Extracellular RNAs from Whole Urine to Distinguish Prostate Cancer from Benign Prostatic Hyperplasia).

A study conducted by researchers at the University of Catania in Italy has found that certain RNAs, including long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs, can effectively distinguish between prostate cancer (PCa) and benign prostatic hyperplasia (BPH). The study used real-time PCR and droplet digital PCR to evaluate the discriminatory power of these RNAs in urine samples from 50 PCa patients and 50 BPH patients. The researchers concluded that miRNAs, such as miR-27b-3p, miR-574-3p, miR-30a-5p, and miR-125b-5p, are more efficient biomarkers for PCa compared to long RNAs. These findings suggest that these circulating RNAs could serve as non-invasive biomarkers for distinguishing between PCa and BPH, potentially reducing cancer overdiagnosis. [Extracted from the article]