Tianjin Medical University Cancer Institute and Hospital Researchers Publish New Data on Biological Factors (Blockade of CD73 potentiates radiotherapy antitumor immunity and abscopal effects via STING pathway).

A recent study conducted by researchers at Tianjin Medical University Cancer Institute and Hospital explores the use of CD73 blockade in combination with radiotherapy (RT) to enhance the immune response against colorectal cancer (CRC). The study found that CD73, an immunomodulatory factor, is upregulated after RT and is associated with poor prognosis in CRC patients. By combining RT with CD73 blockade, the researchers observed a reduction in immunosuppressive cells and an increase in dendritic cells and CD8+ T cells, leading to improved antitumor responses. The study sheds light on the mechanisms underlying the synergistic modulation of immunity by RT and CD73 blockade, offering potential therapeutic strategies against CRC. [Extracted from the article]