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Single Center-Based Real-World Experience on Anti-IL 1 Biological Response Modifiers: A Case Series and Literature Review.
- Source :
- Children; Sep2024, Vol. 11 Issue 9, p1146, 14p
- Publication Year :
- 2024
-
Abstract
- Background: This communication summarizes our single-center experience with the use of anti-IL-1 biologic response modifiers for treating autoimmune and autoinflammatory conditions in children. Methods: We outline our rationale for the off-label use of anakinra and discuss emerging treatment paradigms that necessitate further research and validation. Results: Anakinra has enabled personalized treatment, whether used as a single agent on an as-needed basis, as part of a background treatment regimen, or in combination with colchicine. Our data also highlight the significance of anakinra in treating post-infectious inflammatory diseases, demonstrating its high efficacy in novel applications such as rheumatic fever and post-viral arthritis. Canakinumab, on the other hand, has provided long-term remission. Both medications were well-tolerated, with no serious adverse effects reported. Conclusions: Based on our observations and successful outcomes, we advocate for future collaborative efforts to improve access to anti-IL-1 medications to better manage excessive and harmful inflammation in children. [ABSTRACT FROM AUTHOR]
- Subjects :
- DRUG therapy for arthritis
BIOTHERAPY
DRUG therapy for rheumatism
THERAPEUTIC use of monoclonal antibodies
OFF-label use (Drugs)
COMBINATION drug therapy
JUVENILE idiopathic arthritis
INFECTION
COLCHICINE
DISEASE remission
RETROSPECTIVE studies
PARADIGMS (Social sciences)
PATIENT-centered care
MULTISYSTEM inflammatory syndrome
AUTOIMMUNE diseases
DRUG efficacy
ARTHRITIS
MEDICAL records
ACQUISITION of data
INFLAMMATION
CASE studies
INDIVIDUALIZED medicine
RHEUMATIC fever
VIRUS diseases
MUCOCUTANEOUS lymph node syndrome
INTERLEUKIN-1
DRUG tolerance
THERAPEUTICS
CHEMICAL inhibitors
DISEASE complications
CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 22279067
- Volume :
- 11
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Children
- Publication Type :
- Academic Journal
- Accession number :
- 180018066
- Full Text :
- https://doi.org/10.3390/children11091146