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The Association of Dietary Micronutrient Intake and Systemic Inflammation among Patients with Type 2 Diabetes: A Cross-Sectional Study.
- Source :
- Healthcare (2227-9032); Sep2024, Vol. 12 Issue 18, p1804, 10p
- Publication Year :
- 2024
-
Abstract
- Inflammation contributes to the pathogenesis of type 2 diabetes (T2DM). This study sought to document how the systemic biomarkers of inflammation varied based on food choices among patients with T2DM. This cross-sectional study enrolled ambulatory patients with T2DM. Demographic and clinical information was collected. Five drops of fingerstick blood were collected using an absorbent paper device (HemaSpot HFR). C-reactive protein (CRP), serum amyloid A protein (SAA), and fibrinogen were measured using a Luminex assay. Patient-generated 7-day food diaries were analyzed using a validated food processor software. Data were analyzed by Pearson's correlation tests, linear regression and logistic regression with the significance level set at 0.05. Among the 71 participants, 43 (60.6%) were females. The average age and duration of T2DM were 64.1 ± 10.3 and 15.8 ± 9.1 years, respectively. In a simple linear regression run with selected micronutrients, iron [F (1, 53) = 5.319, p < 0.05, adj. R<superscript>2</superscript> = 0.074] significantly predicted plasma CRP. This significance was lost with multiple linear regressions including age, gender, BMI, T2DM duration, T2DM complications, glycohemoglobin A1c (HbA1c) and other micronutrients. The average intake of most micronutrients by the participants was below the recommended daily intake. A higher intake of iron-rich foods was associated with higher levels of systemic inflammation in a simple linear regression model, but the association was not present after adjusting for patient factors like age, gender, BMI and T2DM-related variables. This relationship needs to be explored further given the key role of inflammation in the pathogenesis of T2DM and its associated complications. [ABSTRACT FROM AUTHOR]
- Subjects :
- RISK assessment
CROSS-sectional method
PEARSON correlation (Statistics)
IRON
IRON in the body
FOOD consumption
BODY mass index
DISEASE duration
GLYCOSYLATED hemoglobin
ACADEMIC medical centers
LOGISTIC regression analysis
SEX distribution
NUTRITIONAL assessment
MICRONUTRIENTS
DESCRIPTIVE statistics
AGE distribution
NUTRITIONAL requirements
ODDS ratio
TYPE 2 diabetes
AMYLOID
FIBRINOGEN
STATISTICS
INFLAMMATION
FOOD preferences
FOOD diaries
DATA analysis software
CLINICS
CONFIDENCE intervals
BIOMARKERS
C-reactive protein
REGRESSION analysis
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 22279032
- Volume :
- 12
- Issue :
- 18
- Database :
- Complementary Index
- Journal :
- Healthcare (2227-9032)
- Publication Type :
- Academic Journal
- Accession number :
- 180013637
- Full Text :
- https://doi.org/10.3390/healthcare12181804